What is already known about this topic? Metals are known to cause DNA damage. What is added by this article?
FIGURE 2
Schematic of Metal-Induced Telomere Alteration Signaling Pathway Linking DNA Damage Response and Activation of DNA Damage, Senescence, and Disease Prognosis
The article summarizes varied ndings of genotoxic effects into speci cally de ned genotoxic endpoints and pro- vides a simple visual comparison of the endpoints in systematic order for each of the metals discussed. What are the implications for envi- ronmental public health practice? By rst ranking metals according to the impact on genotoxic endpoints that could result in cancer and other disease pathologies, researchers can begin to consider developing a suite of biomarkers for early evaluation of vari- ous disease conditions.
Metal Exposure
DNA Damage Response
DNA Break
Telomere Alteration
DNA Repair
Senescence
mitigate toxic health outcomes after exposure to these metals.
Cancer and Other Pathological Conditions
Genomic Instability
Disclaimer: The findings and conclusions in this article are those of the authors and do not necessarily represent the ocial position of CDC, ATSDR, or the National Center for Environmental Health. The use of product names in this article does not constitute an endorsement of any manufacturer’s product. Corresponding Author: Mohammad Shoeb, Oce of Innovation and Analytics, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Preven- tion, 4770 Buford Highway, Mailstop S106-5, Chamblee, GA 30341. Email: ywo7@cdc.gov.
methylation and As-induced mediation of noncoding RNAs (Cheng et al., 2012). In this article, we summarized genotoxic endpoints that have been associated with exposure to these metals in humans and ani- mals. More importantly, some of these metals are known human carcinogens and are rec- ognized as common environmental hazards. We had two primary goals for this initial analysis. The first goal was to use the infor- mation found in toxicological profiles to syn-
thesize accumulating genotoxic endpoints that have been associated with exposure to dierent metals. The second goal was to pro- vide a simple visual comparison of the end- points shown in a systematic order for each of the metals. Activation of genotoxic end- points can progressively alter cellular func- tion and increase susceptibility to various disease conditions. Screening of genotoxic endpoints and genotoxic biomarkers, there- fore, might help the scientific community to
References
Agency for Toxic Substances and Disease Registry. (2005). Toxi- cological profile for zinc . U.S. Department of Health and Human Services, Public Health Service. https://www.atsdr.cdc.gov/ToxPro files/tp60.pdf Agency for Toxic Substances and Disease Registry. (2007). Toxico- logical profile for arsenic . U.S. Department of Health and Human Services, Public Health Service. https://www.atsdr.cdc.gov/Tox Profiles/tp2.pdf
Agency for Toxic Substances and Disease Registry. (2012). Toxicolog- ical profile for chromium . U.S. Department of Health and Human Services, Public Health Service. https://www.atsdr.cdc.gov/Tox Profiles/tp7.pdf Agency for Toxic Substances and Disease Registry. (2020). Toxi- cological profile for lead . U.S. Department of Health and Human Services, Public Health Service. https://www.atsdr.cdc.gov/ToxPro files/tp13.pdf
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December 2023 • Journal of Environmental Health
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